CryoEM Applications and Method Developments

In the Jiang Lab we utilize cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) to study structures of filaments implicated in neurodegenerative disease, human viruses, phages, macromolecular complexes involved in cancer, nanobiology technologies, and drug discovery. We also aim to broaden the applicability of high resolution (2-4 Å) cryo-EM to targets of low abundance or high level of dynamics by experimental and computational methods.