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The Jiang lab is recruiting postdocs in cryo-EM studies of amyloids, virus/host interactions, and protein complexes relevant to cancers. More details can be found at this link

Software

Our research involves developing computer programs that are used in all stages of cryo-EM projects — from sample preparation, data collection, image analysis, 3D reconstruction, structural analysis, and training. The following programs are distributed for free academic use.

CryoVR

Virtual reality-augmented hands-on cryo-EM training

HLM

Classification of helical polymers with deep-learning language models. Publication | Software

HILL Web App

Site 1 (click me) | Site 2 (click me)

HILL

HI3D Web App

Site 1 (click me) | Site 2 (click me)

HelicalLattice Web App

Site 1 (click me) | Site 2 (click me) | Site 3 (click me)

map2seq Web App

Site 1 (click me)

ProCart Web App

Site 1 (click me) | Site 2 (click me)

CTF Simulation Web App

Site 1 (click me) | Site 2 (click me) | Site 3 (click me) | Site 4 (click me) | Site 5 (click me)

Protein-Ligand Binding Web App

The fraction of protein with ligand-bound is a function of protein concentration, ligand concentration, and binding affinity (Kd), not just the molar ratio between the protein and ligand. This Web app will help you better understand the relationship between these 4 variables.

Site 1 (click me) | Site 2 (click me)

Multi-protein Ligand Binding

Site 1 (click me) | Site 2 (click me)

jspr

Software for single particle cryo-EM image processing and 3-D reconstruction. It is built on top of EMAN and EMAN2Publication | Software

MBIR

A cryo-ET 3D reconstruction method that effectively minimizes missing wedge artifacts and restores missing information. Publication | Software

Elliptic distortion estimation and correction

Determine the distortion parameters directly from particle images as part of 2-D alignment without the need of pre-calibration of the microscope. Publication | Available in jspr

Improved 3-D reconstructions of T4 phage after correction of elliptic distortion

s2stigmator

Real-time detection and single-pass minimization of TEM objective lens astigmatism. Publication | Software